I have a primary todo that is heavy read/write of the things I need to do in the next couple weeks. OneNote has a nice drag/drop by line so it's easy to move lines from like Monday to Tuesday, etc.. When ever I think of something I need to do, I add it to the list somewhere, and whenever I'm not doing anything, I open the file and pick something to do, when it's done, I delete it from the list.
Lower down in the todo I have things I need to keep my mind on, but doesn't have like a specific date. Like I have list of things on want to read/watch/listen to/play in the near term, like 5 items each. I have longer lists of each of those as separate notes with like a hundred items each. Near term health stuff I need to monitor. Some back burner tasks, etc.. I try to not let the todo list overall get too big, and will once in a while go over it, and clean it.
The todo is just one note of like a hundred. I have a note of like 'quick references' important addresses, account numbers, identity numbers, vehicle vin/license, insurance numbers, airline mile numbers, etc.. That's a very useful note. So that's like in a Main section, I also have Self, Recreation, Future, Thoughts sections my Personal notebook.
The Self section has like health info/logs/history, car info, house, finances, taxes, even like a list of gifts I've given people for holidays as a good reference for next year (15 years of gifts in a single note). Every time I get sick I add to my health log note: got sick on this date, this is what happened, etc..
Recreation section has notes for movies, tv shows, video games, music, friends, places I'd like to travel to, podcasts, even a Halloween costume list of ideas and costumes I've decided on over the years.
Future is like future plans for work, housing, life, finances, etc.. Thoughts section is like notes for app ideas, thoughts on people, my jobs, random thoughts, like blog post ideas, etc.. I'm always thinking of some random thing and cataloging it away in a particular thought note by subject.
I also have a private section that is password protected with even more personal stuff in it. Each of the programming projects have their own section
There's a Projects notebook with sections for each of my work and personal programming projects, and each of those sections have notes like todo, design, operations, etc..
Search is really nice in OneNote as well, I can just hit ctrl+E and get full text search, quickly jump to a particular note file, or line in a note with matching text. So ctrl+e, enter AA, hit return and it'll open my Quick Ref note right on the line with my AA miles number on it.