It's hard to know what to make of this because while you've included the output JSON you haven't included the input PDF so I have no idea how to interpret what it's actually doing.
No, just as I meant it.
But I honestly don’t remember what the causes where; it was over 10 years ago and lessons were dense in information.
I can only recall a few tidbits here in there, including the specifications of a, as of now probably outdated, surgery probe meant to detect isotopes.
It was awesome! Swappable tips, a main unit on a wheeled stand giving it great mobility and awesome battery life! A great tool! Still don’t get the point of learning about it in first year though ¯\_(ツ)_/¯
Oh, and throwing dwarves in nightclubs is unethical, even with the dwarf's consent, because human dignity is inalienable.
I'm pretty busy so I can only do a cursory search. I cannot find the source I originally read this on, however I will try to find it when I am at home.
Here's what I could find via a preliminary Google search on my phone:
From drugabuse.gov [0]:
> In the aforementioned study, abstinence from methamphetamine resulted in less excess microglial activation over time, and abusers who had remained methamphetamine-free for 2 years exhibited microglial activation levels similar to the study’s control subjects. Another neuroimaging study showed neuronal recovery in some brain regions following prolonged abstinence (14 but not 6 months). This recovery was associated with improved performance on motor and verbal memory tests. But function in other brain regions did not recover even after 14 months of abstinence, indicating that some methamphetamine induced changes are very long lasting.
Here's a graphic they included [1].
This is another source [2]:
> Stopping drug use doesn’t immediately return the brain to normal. Some drugs have toxic effects that can kill neurons—and most of these cells will not be replaced. And while changes to connections between neurons in the brain may not be permanent, some last for months. Some research suggests the changes may even last for years.
I cannot find the studies these articles cite, but I'll try to find them later.
This is related, but is not specific to stimulant or methamphetamine use:
Delta-FosB, an enzyme that is critical to achieve an addiction state in the brain, has a half-life of ~208hr [3]. Multiply that by the standard 7 half-lives to estimate significant elimination, and that alone yields a maximum of 60 days until it is cleared. This enzyme is key in drug and behavioural addictions.
This paper [4] speculates about changes in the brain that last longer than the time it takes to eliminate elevated Delta-FosB levels in the brain.
Poor Man's SQL Formatter for Notepad++ can do it, it leaves a lot to be desired though in terms of customization. It has saved me a lot of times, since I'd rather read Poor Man's code than the code of the other people.
I am using Jetbrains Datagrip to write SQL all day, every day. It can auto-format SQL just like all their other tools can auto-format the language in use. It also has a bunch of other handy stuff like symbol completion from the current database.
Apple said on Tuesday it saw a nearly 30 percent decline in its China revenue in the quarter ending September, the highest fall among all regions, due to tepid demand for its iconic iPhones.
Could you link to the CDC claim that 30% of the US population shows signs of exposure to spinal meningitis? I'm unable to find any references. Personally, I find this quite probable, since antibiotics are already known to reliev some back pain.
Errr, spontaneous mutation?? Selection pressure for such mutations that are still survivable for the bacteria?
I just described a very rough screening method, pcrh quotes from the Nature article other extreme efforts tried. These don't produce specific types of mutations, they just discover if there are any "easy" ones. E.g. the E. Coli antibiotic I mentioned had to be transported across the membrane bacterium by a protein.
The lab I did part of a summer's research was working with the enterobactin iron scavenging mechanism in E. Coli (https://en.wikipedia.org/wiki/Enterobactin). If grown in seriously iron free condition (e.g. glassware was soaked in HCl, and then bathed in deionized water for days), it would synthesize iron binding enterobactin and send it out into the environment, and there was a protein on the membrane surface that would accept the enterobactin+iron complex.
This also turned out to be the protein that accepted this antibiotic into E. Coli. It appeared that some of the mutations that allowed this were either point or deletion mutations of that protein, either it was deranged or cut off in some location, or outright deleted (missing from the bacteria's set of genes in its DNA).
So this survival mechanism is one of just not letting the antibiotic inside in the first place, which is how it appears teixobactin producing bacteria survive it. They appear to synthesize and expel it, and they don't have cell walls allowing it to get back in.
https://github.com/maurycy/gemini-json-ocr